Prognostic Significance of Strain Imaging in Amyloidosis

Prognostic significance of strain imaging in amyloidosis.

Prognostic significance of strain Doppler imaging in light-chain amyloidosis.

OBJECTIVES To clarify the prognostic value of strain and strain rate imaging in light-chain (AL) amyloidosis. BACKGROUND Myocardial strain and strain rate Doppler imaging are objective measurements that may detect regional subtle myocardial functional abnormalities in patients with amyloidosis. METHODS We prospectively examined 119 consecutive, untreated patients with biopsy-proven AL amylo...

Cardiac magnetic resonance strain imaging in systemic light chain amyloidosis

Background Systemic light chain amyloidosis (AL) is associated with a high cardiovascular morbidity and mortality. Cardiovascular involvement and determination of prognosis is underestimated by standard imaging parameters. Recently, cardiac deformation analysis of global circumferential and longitudinal strain has been shown to have great clinical impact on the assessment of prognosis and survi...

Longitudinal Strain Imaging in Light-Chain Cardiac Amyloidosis

The systemic amyloidoses are a group of uncommon diseases characterized by extracellular accumulation of fibrillar proteins, leading to loss of normal tissue architecture and function (1). Light-chain (AL) amyloidosis, which is probably the most frequent form, can potentially involve any organ, but when the heart is affected, the outcome is particularly poor, with a median survival of 4 to 6 mo...

Prognostic significance of Doppler measures of diastolic function in cardiac amyloidosis. A Doppler echocardiography study.

BACKGROUND We have previously characterized the left ventricular diastolic filling abnormalities in cardiac amyloidosis by Doppler methods. The various filling patterns were shown to be related to the degree of cardiac amyloid infiltration. The purpose of this study was to determine the value of Doppler diastolic filling variables for assessing prognosis in cardiac amyloidosis. METHODS AND RE...